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\section*{Structure-activity rules in suramin analogues}
Suramin analogues act as anti-cancer agents by interfering with 
the formation of blood vessels for the tumour. Using the atomic
structure and bond relationships present in such compounds,
the task for an ILP system is to discover structural features
that can be used to improve such compounds. The data
here are described in \cite{drugs:suramin}. In collaboration
with Professor Harris (Institute of Molecular Medicine, University of Oxford),
the ILP system {\em Progol\/} \cite{mugg:progol} was used
to suggest several novel structural ideas 
that will be incorporated in the synthesis of new compounds.

All data is as used in the {\em Progol\/} experiments, and contained
in a single compressed file with a ``.pl.Z'' suffix.
Each compound has associated ``atm'' and ``bond'' predicates
describing its atomic and bond structure. These were obtained
using the QUANTA molecular modelling package. There are 7 positive
examples and 4 negative examples (expressed as negative ground
clauses).

\begin{thebibliography}{}

\bibitem{drugs:suramin}
Braddock, P. S., D.-E. Hu, et al. (1994).
A structure-activity analysis of the 
growth factor and angiogenic activity of basic fibrobalst growth factor by 
suramin and related polyanions.
{\sl Br. J. Cancer.\/} 69: 890-898.

\bibitem{mugg:progol}
Muggleton S.H. (1995)
Inverse Entailment and Progol.
{\sl New Gen. Comput.} (to appear).

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